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"tightly entangled" is a perfectly correct and usable phrase in written English.
It is often used to describe a complex or difficult situation. For example: The two countries were tightly entangled in a trade dispute.
Exact(2)
Shutdown of these genes was earlier associated with HCC or with tumors of other entities [ 24– 26], but our findings highlight that targeted repression of these anti-proliferative genes might be tightly entangled with an early onset of malignancy.
What should be noted is, shorter genes consume fewer energy is only an intuitive judgment, which overlooks the fact that evolution of gene structure and expression pattern are tightly entangled together.
Similar(58)
The hydrogels that were formed from polymeric micelles possessing a tightly packed (i.e., well-entangled) inner core exhibited a higher storage modulus than the hydrogels that were formed from the polymeric micelles possessing a loosely packed structure.
YK20 formed tightly aggregated coils at low ionic strength, but networks of entangled chains with a porosity of ~0.5 3 μm at higher ionic strength.
He became entangled and stumbled.
All, naturally, become entangled.
Emwazi remained entangled with MI5.
Wires can easily become entangled.
Its history is entangled with America's.
Mortality rates for entangled animals are high.
Some are entangled in power lines.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com