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As a proof-of-concept experiment, a calmodulin (CaM /calcineurin (Cn) pair was chosen to screen α-helical peptide ligands that tightly bind to CaM and also control enzymatic functions of Cn.
Because the protons bound to terminal Q1 units in phosphate chains tightly bind to oxygen atoms, as opposed to the protons bound to inner Q2 units in phosphate chains, we attributed the reduced mobility of proton carriers upon introducing AlO3/2 and/or YO3/2 into 1W glass to the shortening of phosphate chains.
So a team led by geochemist Roy Wogelius of the University of Manchester in the United Kingdom set about to bypass the melanosomes and look directly for traces of the pigments themselves, which often tightly bind to elements such as copper, cobalt, zinc, and calcium.
In the open conformation, two serines and a threonine residue tightly bind to the metal ion, and two water molecules also bind directly to the metal ion, similar to that described above for TEM8.
This is accounted for by the so-called hydration repulsion [16] [20] arising from water molecules that in aqueous electrolytes tend to tightly bind to ionised surfaces like membranes.
Among other SUR regions that interacts with Kir6.2[10], one of the transmembrane domains of SUR, TMD0, is known to tightly bind to Kir6.2 and to facilitate its trafficking to the plasma membrane[11], [12].
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When you're more tightly bound to an agreement than your counterpart is, trouble could follow.
During synthesis, hydroxyl groups from the water stayed tightly bound to the lead oleate.
He still seems tightly bound to Dortmund – but will this always be the case?
They call it "community access," because each station is so tightly bound to its community.
No American poet seems more tightly bound to a fixed landscape than he to the California coast.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com