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The S. cerevisiae Atg19 cargo receptor contains multiple low-affinity Atg8 binding sites that enable it to selectively and tightly bind to membrane-localized Atg8 (Sawa-Makarska et al., 2014).
These genes encode Argonaute 1, 2 and 4 proteins, which participate to the RNA-induced silencing complex (RISC) and tightly bind the single strand miRNA in the cytoplasm before their binding to the cellular or viral target mRNA [4].
Localization of multiple Fc-binding domains on the hexameric core allowed the Hex nanocarrier to tightly bind antibody with sub-nanomolar affinity regardless of pH and the antibody's originating species.
Accordingly, the following catalytic sequence is proposed (depicted in Figure 6): It is assumed that PGG2 has a high binding affinity for the peroxidase site of the enzyme and will tightly bind to this site.
Long timescale explicit solvent molecular dynamics (MD) simulations of PDC109, in the presence and absence of PhC, suggest that PhC binding strongly correlates with the relative orientation of choline-phospholipid binding sites of the two Fn2 domains; unless the two domains tightly bind PhCs, they tend to change their relative orientation by deforming the flexible linker.
Based on the free energy calculations and structural analysis, we predicted that the ethylenediamine group would tightly bind to Asp84, and the trifluoromethyl group should occupy part of substrate arginine binding site, which is consistent with our original goal.
The United States wants several things from Pakistan, and the sale of F-16's could more tightly bind the two nations.
Indeed, recent strategy within Microsoft has, if anything, drifted in the opposite direction -- to more tightly bind its various groups together.
But the cables make clear it is about money too; there are a plethora of business ties that tightly bind the Chinese and North Korean elites.In one remarkably frank account, a senior Chinese official told an American diplomat how North Koreans had been selling mineral rights to Chinese investors in contravention of official policy, to raise enough cash to build 100,000 apartments in Pyongyang.
These include a "peace-building commission" for war-torn countries, a new human-rights council that does not let countries like Libya and Sudan (as now) become members, a fund for promoting democracy and a definition of terrorism that would more tightly bind states to fight it.
SA is a homo-tetramer protein, and each subunit can tightly bind to biotin molecule.
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The phrase "tightly bind " typically functions as a verb phrase , describing the action of creating a strong and secure connection between two or more entities. This is supported by Ludwig examples illustrating both physical and chemical binding scenarios.
Expression frequency: Very common
