This particular case is an excellent illustration of the tight interconnection between politics and science, and highlights how fast this narrow equilibrium can be disordered.
It is clear that there is a tight interconnection among wound healing, fibrosis and a variety of chronic disease conditions, demonstrating the heterogeneity of this pathology.
Due to the tight interconnection of drinking water and groundwater, the latter is submitted to the same limit values (0.1 µg/L for single substances and 0.5 µg/L for the sum of substances, Groundwater Directive 2006/118/EC) [2006/118/EC
Taken together, these findings indicate a tight interconnection of the endosomal and autophagosomal trafficking routes.
The main transcriptional response indicates a tight interconnection between the individual pathways of the glucose regulatory system.
The tight interconnection between the different pathways of the glucose regulatory system is reflected by the main transcriptional response observed.
This review aims at providing novel insight into the regulatory pathways of autophagy in response to glucose and amino acid deprivation, as well as their tight interconnection with metabolic networks and redox homeostasis.
At the same time, emerging data from multiple animal studies and clinical investigations suggest a tight interconnection between Aβ and pTau, and therefore, development of strategies to reduce levels of both could be beneficial (Jack and Holtzman, 2013, Mondragon-Rodriguez et al., 2012).
Altogether, the above observations indicate that peripheral tissues and draining LNs operate as a functional unit during chronic inflammation, and full understanding of how local pathological processes originate and progress cannot disregard the analysis of the tight interconnection and reciprocal modulation between the two compartments.
Since type of cancer may influence symptom profile (e.g., breathlessness may be more common in lung cancer than in prostate cancer), there remains the possibility of finding even tighter symptom interconnections and simpler causal models for specific cancer types.
