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Alternatively, given the tight threshold for in vitro cytotoxicity of this drug, it is conceivable that higher doses or a longer treatment schedule (beyond 4 weeks) is required to observe an effect of FP in the PER-403 xenograft.
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We use a technique that we call bin-covering that we apply uniformly to get (asymptotically) tight thresholds for each of these properties.
The presence of these feedback loops have been shown to produce switch-like (i.e. bistable) responses to receptor activation, allowing for a tight threshold of cellular response during development [ 50, 51].
The National Institute for Occupational Safety and Health had recommended a tighter threshold of 1.0.
A tight threshold will in general filter the presence of different phenotypes.
A variable and tight threshold was set to eliminate residual background.
The analysis was subsequently repeated on a more restricted pool of items those selected for the long scale IONB-QoL through the CTT, and those selected by using a tighter threshold range (0.5÷1.5) considered to be productive for measurement [ 28].
The cooperativity in the complex formation may itself serve the purpose to set up a threshold for the tight regulation of caspase activation and apoptosis.
The incremental step pulse programming (ISPP), which is the most widely used programming scheme, was proposed to maintain a tight cell threshold voltage distribution for high reliability[7, 8].
Unless linkage is very tight, the selection coefficient a must be above a threshold for A1 to effectively withstand gene flow (this threshold is implicitly defined by Equation 10).
This "dual modulation by cGMP" may have evolved to allow a tighter control of HCN channel activity, and thus, a better control of the threshold for activation of neurons.
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CEO of Professional Science Editing for Scientists @ prosciediting.com