Additional file 2 gives a detailed overview of the comorbidities.> -wrap-foot> Adverseveventevent; COBRA Slim, COmbinatie therapie bij Reumatoïde Artritis; MTX-TSU, Methotrexate with tight step-up, 15 mg of MTX weekly, no oral steroids allowed.
Low-risk patients were randomized to one of two treatment arms: MTX tight step-up (MTX-TSU): 15 mg of MTX weekly, no oral steroids allowed COmbinatie therapie bij Reumatoïde Artritis (COBRA Slim): 15 mg of MTX weekly with a step-down scheme of daily oral GCs (30 20 12 mg, 5-10-7.5 and 5 mg of prednisone).
Patients were randomized to 15 mg of MTX weekly (MTX with tight step-up (MTX-TSU)) or 15 mg of MTX weekly with prednisone bridging, starting at 30 mg and tapered to 5 mg daily from week 6 (COmbinatie therapie bij Reumatoïde Artritis (COBRA Slim)).
Top vets are on hand in case of injury, security is tight, and rigorous steps are taken to guard against infection.
PRINCETON, N.J. — Twenty minutes before Cornell's game against Princeton tipped off on Saturday, five Tigers football players, wearing black masks with matching body paint and tights, stepped onto Carril Court by the basket where the Big Red was warming up.
Actually the stability condition may imply very tight time step constraints.
We apply our new framework for forces on a Lagrangian mesh to the case of a surface tension force, which when treated explicitly leads to a tight time step restriction.
The molecular organization of clathrin in the coat in particular, the position of the specific Hsc70 attachment site at the base of a constricted funnel of criss-crossing ankles has evolved to allow the tight attachment step in Hsc70 binding to capture a destabilizing fluctuation in clathrin conformation, so that build-up of strain at multiple vertices ultimately leads to dissociation.
Eventually, everyone pulls on a coat, grasps a suitcase tight and steps towards the forbidding unknown.
