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Since the AHL autoinducers synthesized by a bacterium are species-specific, tight specificity in the native AHL signal synthesized by each bacterium is critical for efficient interbacterial communication.
The tight specificity of this putative regulatory motif implies the existence of a transacting factor(s) that is relatively specific for MT genes.
The hallmark of an efficient quorum sensing system relies on the tight specificity in the signal generated by each bacterium.
Bacterial transmission in novel species suggests absence of very tight specificity in the molecular interactions required, or considerable evolutionary conservation of the host molecules exploited.
Such tight specificity of methylation in one gene for a single tumour type is unusual and raises the potential to use detection of methylated DNA either in tissue or body fluids as a cancer biomarker.
The proliferation of these new designer nucleases has occurred over a very short period of time, and they have yet to be developed into truly foolproof tools that offer consistently high targeting efficiency with tight specificity in every system.
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These results offer insights into understanding the molecular basis of tight signal specificity observed in B. mallei quorum sensing.
The tight tissue specificity for DON production observed in the rachis tissue suggests that any DON-inducing factors are likely to be preferentially synthesised in this zone.
To put this in simple terms, BmaI1 should be able to selectively recognize native acyl-ACP from non-native acyl-ACPs in the cytosol to achieve tight signal specificity.
This includes the selection of important new probe targets, synthesis of novel probes which are capable of targeting and exploring new classes of enzymes and their poorly understood catalytic mechanisms, tight substrate specificity, and/or low expression levels in biofuels development.
The "cautious" (or class A) monooxygenases, which are typified by the extensively studied p-hydroxybenzoate hydroxylase (PHBH) (reviewed in refs (31− 33)), have a stringent substrate specificity and also maintain tight regulation over the reductive half of their reaction cycle.
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CEO of Professional Science Editing for Scientists @ prosciediting.com