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But a tight site on a major urban corner turns out to have inspired Hadid, not confined her.
"It's a very tight site," said Kenneth J. Ringler Jr., who was appointed executive director of the Port Authority of New York and New Jersey in October.
The building has been shoehorned into a tight site southeast of City Hall and across the street from Pace University, and so, as with most tall buildings in New York, you don't see it all at once.
These contortions are a sly expression of the various forces that this architect had to contend with while designing the building: the tight site, the restrictions imposed by the zoning envelope, the developer's desire to squeeze out as much rentable space as possible.
It is a vast building, cleverly shoehorned into a tight site by Irish architects Heneghan Peng, whose small office is used to tackling projects of an unlikely scale and international scope – from the gargantuan Grand Egyptian Museum being built near the pyramids of Giza, to the Palestine Museum under construction in the West Bank, and the Stirling prize-shortlisted Giant's Causeway visitor centre.
(2011) that allosteric activation is due to binding at the tight site, whereas the effect on dephosphorylation is due to binding at the weak site.
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Although lending has slowed and credit is tight, sites like LendingTree, Bankrate, SmartHippo and other sites still provide a valuable marketplace for finding mortgages for those who still qualify.
While a slew of random eyeballs won't cut it anymore (especially in a recession when ad budgets are tight), sites that demonstrate proven, direct links to coveted consumers can still thrive.
Sony reportedly spent over $170 million after the PSN hack to cover the cost of identity theft insurance for customers, hacking investigators, tighter site security and more.
The tighter site binds AMP, ADP, and ATP competitively with NADH, whereas the weaker site does not bind NADH, but is responsible for mediating the protective effect of ADP on dephosphorylation.
In contrast with the tight active site, the large open-entrance of SAM/SAH binding site (Fig. 4C) allows for free entry of SAM and exit of SAH during successive methylations.
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