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In fact, since Rb is at the center of a large protein interaction network, fast and tight recognition provides an advantage for disruption by the viral proteins, where the balance of physiological and pathological interactions is dictated by kinetic ligand competition.
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Compared with the Dpo4 polymerase that shows nearly no changes in the emission spectra at the binding interface in the complexed states, the pol β complex shows spectral changes and suggests tighter recognition.
IgG1 is a critical defense protein that recognizes specific pathogen epitopes through tight binding, antigen recognition domains and triggers a pro-inflammatory, pathogen-destroying immune response through the Fc region.
Although algorithms are tighter, bedrock speech recognition techniques haven't changed very much since 1976, when the first publicly traded speech software company brought its wares to market and then went belly-up.
In contrast to tight coupling between promoter recognition and transcription bubble formation at most bacterial promoters, in eukaryotes promoter recognition, RNAP II recruitment, and promoter opening appear to be uncoupled.
The acetaldehyde affects the structure of the cellular membrane, which leads to disruption of tight junctions, increased immune recognition of certain antigens, cell damage, DNA damage, and mutagenesis (Setshedi et al. 2010; Thiele et al. 2008).
The recognition that a tight glycaemic control significantly reduces the microvascular and macrovascular complications in T2DM indicates hyperglycaemia as the main goal of treatment.
Recognition of the tight economic margins prevailing in modern poultry production and the impact of avian coccidiosis on poverty in many parts of the world has highlighted a requirement for a panel of straightforward and sensitive, but cost-effective, Eimeria species-specific diagnostic assays.
Recognition of the tight economic margins in modern poultry production [ 15] and the impact of avian coccidiosis on poverty in many parts of the world, especially Asia [ 16], has highlighted a requirement for a panel of straightforward and sensitive, but cost effective, Eimeria species-specific diagnostic assays.
A more rigid structure, however, improves substrate recognition, allowing for tighter substrate binding and lower Km values.
The current need to rebuild the city, and the public's recognition that finances are tight, have also taken some of the partisanship out of City Hall politics.
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