A concise literature study about Doppler and duplex sonography of carotid arteries, a brief lecture and 1 h of hands on training and tight observation by a neurologist specialist (or vessel surgeon, neurosurgeon, neuroradiologist, anesthesiologist, angiologist whoever is competent in this method) in the first ten measurements may support to gain and maintain this knowledge.
If absence of SIRS is used as an exclusion criterion for tight observation and aggressive treatment, a prognostic sensitivity of about 60% is hardly satisfactory, and this finding is clearly clinically relevant.
Both MI and single regression (panels E and F) show a tight cluster of observations around the line of agreement (the diagonal line).
Responses to FP were very reproducible with cytotoxicity occurring within a remarkably tight dose range, an observation we have also made when using this drug in other cancers (Beesley et al, 2007).
The observation of tight mutant load stability, both across tissues and with time, in all tested fetuses, suggests that mtDNA segregation is mainly governed by random genetic drift in somatic tissues throughout the entire period of human embryofetal development.
The observation of tight interplay between PRCs and RNAPII at 1,065 silent PRC targets associated with RNAPII-S5p+S2p−8WG16− led us to investigate other RNAPII variants within the whole cohort of PRC targets (5,628 genes), which includes genes with substantial mRNA expression.
It's a vacuum-packed anthology of tight arguments and shrewd observations.
Such a rigorous modeling approach critically depends upon a tight link between experimental observations and model design, simulation and verification.
In particular, in Robo1 knockouts, thalamocortical and corticothalamic axons reach their targets earlier than in control mice and callosal axons form tight bundles, contrasting with observations in Slit mutants where axons appear to defasciculate (Bagri et al. 2002; Andrews et al. 2006).
Therefore, the aforementioned in vitro observations indicating tight coupling of Grx1-roGFP2 to glutathione (and relative indifference to PDI) suggested that the rate of re-oxidation of an ER-localized Grx1-roGFP2 probe following a reductive pulse might be affected by the presence of glutathione in the ER lumen.
Indeed, knowing the change point restricts the search efforts to a tighter window of observations and related variables.
