The function of cingulin is presently not fully understood, but the cingulin protein has been reported to be present in tight junctions interacting with the tight junction protein ZO-1 [ 49].
Despite its typical location below tight junctions, it interacts with several bacteria, facilitating internalization and colonization.
What are the differences between tight and weak interacting complexes?
Therefore, in response to claudin disruption, claudin and occludin move out of the tight junction and interact with the key protein components of the intrinsic apoptotic signaling pathway.
PARD3 is a member of a family of adaptor proteins playing a central role in the formation of epithelial tight junctions by interacting with other members of the PARD family of proteins [ 40].
Indeed, in epithelial cells, ZO-1 is concentrated in tight junctions, where it interacts with integral transmembrane proteins including occludin, claudins and JAMs (junctional adhesion molecules), which are specifically enriched at this type of junctions.
It is this unforeseen sequence of events, resulting from what accident theorists call the "tight coupling" of complex interacting systems, that causes accidents.
Ragged zones of hot color, like open wounds, interact with tight, buzzing linear glyphs — fragments of organic life — that bespeak the artist's lingering debt to Surrealism, all in concert with intuitions of a new, expansive kind of pictorial space.
In the cortex, neurons are arranged in arrays of cortical columns that interact in tight loops with their underlying subcortical nuclei.
These results suggest a tight regulation of MDM2 interacting with p53.
