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We surmised that this impression reflects an accidental bias in the selection of monitoring sites towards those with prevailing vertical hydrological flowpaths, rather than a tight causal link between vegetation cover and erosion alone.
The fact that macrophage, T cell, ECM and endothelial-specific genes form independent clusters, indicates that there is not a tight causal relationship between them.
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The results demonstrate a tight and causal link between asynchronous GABA release and tonic inhibition.
Moreover, when using a higher SNP density, the small extent of LD in crossbred populations may be an advantage for genomic selection because the tight linkage between causal polymorphisms and adjacent SNPs is less likely to be broken down by recombination, and therefore the accuracy of genomic predictions will persist over more generations [ 32].
If in spite of the broader TCR, external calcium effects remain negligible at room temperature, then the case of tight coupling as a causal link will be much strengthened.
This makes it very unlikely that our results are due to a tighter linkage disequilibrium between causal SNPs and the studied SNPs in the Southern subjects.
Instead, we think it is more likely that f68558 is in tight linkage disequilibrium with the causal mutation that is possibly located in the regulatory region (e.g. promoter) of PROP1.
To establish a causal relationship between tight glucose control with intensive insulin therapy and mortality, randomized controlled trials were performed in the critical care setting to assess the impact of preventing and/or treating hyperglycemia as compared with tolerating hyperglycemia.
However, existence of multiple causal variants in tight linkage is plausible, for instance if any of several mutations within a single gene, or combinations of those mutations, alter disease susceptibility.
The landmark study by van den Berghe and colleagues in 2001 provided evidence for a causal link between tight glycemic control and reduced morbidity and mortality in a surgical ICU population [ 3].
Since type of cancer may influence symptom profile (e.g., breathlessness may be more common in lung cancer than in prostate cancer), there remains the possibility of finding even tighter symptom interconnections and simpler causal models for specific cancer types.
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