On the circuit the two suspended Sky comperes are a tight double act.
At the Rose Bowl, where college football clings to tradition with white-knuckle fervor, fullbacks can still be in vogue, tight ends act as primary pass catchers and the punter can be valued as a skill position player.
It's a tight balancing act, but one which seems to have encouraged investors.
Under normal conditions, tight junctions act to segregate a growth factor within the apical membrane compartment away from its receptor in the basolateral membrane compartment, thereby precluding receptor activation [19].
Tight junctions act as a primary barrier to the diffusion of solutes through the intercellular space and also have an important role in creating a boundary between the apical and the basolateral plasma membrane domains, allowing the specialized functions of each surface to be maintained [2].
Endothelial tight junctions act as a natural barrier for the vascular spread of cancer cell, by keeping the circulating cancer cells 'at bay-in the circulation'.
In epithelial cells, as well as being a permeability barrier, tight junctions act as a strong cell adhesion mechanism and have a potential tumour suppressor role [ 25].
Thus, tight junctions act as gates, which regulate paracellular permeability of ions and other small solutes, and fences, which restrict the diffusion of apical and basolateral or luminal and abluminal membrane components.
The increase in E-cadherin expression was also verified by immunohistochemistry. Tight junctions act as a critical barrier to the passage of substances between the vasculature and the interior lumen of glands [ 35] and together with gap junctions help maintain the overall stability of the epithelial layer structure [ 36].
Or his flip-flop might underscore the tight-wire act he has to tread to avoid trampling Smith's confidence.
