The first idea I had for the book was Chapter Fourteen, where Sarah's boyfriend insists on wearing a "tie substitute".
The most likely scenario is that an ancestral, single Tie gene was required for heart development and that, after genome duplication, functional divergence occurred within the vertebrate lineage: in fish, functional redundancy has been conserved between Tie-1 and Tie-2 in respect to cardiac development, whereas, in mice, Tie-1 cannot substitute for a loss of Tie-2 function in the early heart.
As Geoff Hurst scored his hat-trick for England in the 1966 final, the man he replaced, Jimmy Greaves, was watching from the sidelines, dressed in a suit and tie, because substitutes were not permitted at the World Cup until 1970.
John Roberts, sporting an aggressively aquamarine tie, is substituting for Chris Wallace today, lending the proceedings a sort of "Generic Inflatable News Anchor" feel to a space that's typically filled by Wallace's archness.
Try using pipe cleaners, rubber bands, thread, or twist-ties as substitutes for wire at the center of your flower.
The substitute Robin van Persie tied the match, and United added goals by Wayne Rooney and Javier Hernandez.
A portrait painter was called in to paint out Uncle Wilhelm's uniform and substitute white tie and tails.
Henri Lansbury put the Gunners ahead in the 15th minute Tuesday at White Hart Lane, but the Tottenham substitute Robbie Keane tied it in the 49th.
Dhurgham Ismail calmly converted from the spot with just four minutes left on the clock before Iran substitute Reza Choochannejhad tied the scores again two minutes from the end of a classic, heart-stopping match.
We argue that the benefit they get from social ties can be partially substituted.
