These membranes tubules formed bridges between physically separate mini-stacks, thus mediating their coalescence into intact Golgi ribbons.
The nanoparticle form of Cu was proved to have a unique advantage over Cu2+ in entering the bacterial cells, thus mediating specific effects (e.g. DNA oxidative damage) [2].
DAXX interacts with the E3 ligase Mdm2 in PML nuclear bodies and prevents its self-ubiquitination, thus mediating the proteolytic degradation of p53 (Tang et al., 2006).
Pregnancy-associated plasma protein A (PAPP-A) is a trophoblast-derived, IGF binding protein protease that increases IGF bioavailability, thus mediating trophoblast invasion of the decidua.
Touch is a powerful conduit for emotional connectedness, and thus mediating haptic (touch) displays have been proposed to address this deficiency; but suitable evaluative methodology has been elusive.
All CK isozymes catalyze the reversible transfer of γ-phosphate from ATP to the guanidino group of Cr to generate PCr and ADP, thus mediating efficient cytosolic storage of high-energy phosphates for rapid, focal ATP replenishment.
This architecture allows direct flow of Ca2+ ions from Ca2+ channels to synaptotagmin, which then triggers fusion, thus mediating tight millisecond coupling of an action potential to neurotransmitter release.
Accordingly, the coil 1A domains might "switch" from a dimeric α-helical coiled coil into a more open structure, thus mediating, within the ULFs, the conformational rearrangements of the tetrameric subunits that are needed for the intermediate filament elongation reaction.
However, vectors expressing short hairpin RNAs (shRNAs) and/or synthetic siRNAs designed to mimic endogenous 21-nt siRNAs can be manually introduced into mammalian cells to avoid the interferon response, thus mediating gene silencing without significant adverse effects (Elbashir et al., 2001; Kim and Rossi, 2007).
To date, more than 800 miRNAs have been identified in humans, each of which targets multiple functionally-related genes, thus mediating complex regulatory networks [3], [4].
TRPV1 is involved in the transduction of noxious heat and a receptor for capsaicin, thus mediating heat hyperalgesia after stimulation with this hot chilli constituent [5].
