Sentence examples for thus far observed from inspiring English sources

Sometimes, CYP or FMO bioactivate chemicals to reactive metabolites but to date, drug toxicity thus far observed in the clinic is mainly the result of CYP-dependent oxidation.

In the STG [6], [12] and the cardiac ganglion LCs, all correlations thus far observed are positive correlations.

The feasibility and positive feedback from patients and GPs alike have been encouraging outcomes thus far observed in the study process.

All studies of diurnal and circadian expression of Physcomitrella genes have thus far observed clear cycling under light-dark cycles (LD) and/or in DD, but rapid dampening of the rhythm in LL [[ 52- 56]; our own unpublished data].

The among-lineage and among-gene variation in rate dynamics observed in snakes is the most extreme thus far observed in animal genomes, and provides an important study system for further evaluating the biochemical and physiological basis of evolutionary pressures in vertebrate mitochondria.

It is noteworthy that in contrast to reports of aggravation by ascorbate of nickel-mediated in vitro toxicity (Kasprzak and Hernandez 1989), consistent with the known generation of reactive oxygen species in metal ascorbate solutions (Buettner and Jurkiewicz 1996), no such effects have been thus far observed in nickel-exposed and ascorbate-supplemented cells and tissues.

(Element 118 is also radioactive, but, since only three atoms of this element have thus far been observed, its physical and chemical properties cannot be documented).

However, no tau mutations have thus far been observed in AD.

However, in the three neighborhoods revisited thus far, we observed significant decline in the health status of some participants.

33, 75 No other clear, recurrent, genetic changes have thus far been observed in osteosarcoma, although putative genes and pathways have been explored, including HER2.

Remarkably, genes acting at the center of the PIN tend to be more selectively constrained than those acting at the network periphery, a pattern that has thus far been observed in Escherichia coli, yeasts, worms, flies, and mammals (Fraser et al. 2002; Jordan et al. 2003; Hahn and Kern 2005; Lemos et al. 2005; Davids and Zhang 2008; Alvarez-Ponce 2012).