Sentence examples for thumb subdomain from inspiring English sources

Based on this analysis, we define at an atomic level an NS5B homomeric interaction model that connects the T-helix in the thumb subdomain of one monomer, with the F-helix of the fingers subdomain in other monomer.

The thumb subdomain has four α helices.

The TC tag was inserted into the RT "thumb" subdomain between β14 and αH or between αI and αJ to generate the HIVRTt1 and HIVRTt2, respectively.

On the other hand, insertion of the TC tag at the N- and C-terminus as well as in the flexible "thumb" subdomain of the RT dramatically affected virus production, entry and infectivity.

It belongs to the thumb subdomain and points towards the active site in the palm.

(3) Two Zn ions were found, one in the fingers and one in the thumb subdomain.

These structures share several common architectural and structural features observed in other DNA polymerases, including a hand-like architecture with fingers, palm, and thumb subdomains.

By comparing the collective motions of the MD and crystallographic structures, we demonstrate that the chief effect of NNRTIs is to constrain a key rigid-body motion between the "fingers" and "thumb" subdomains of the p66 subunit.

The fingers, palm and thumb subdomains of p66 form a nucleic acid binding cleft and the connection subdomains of the two subunits form the floor of the nucleic acid binding site [4] [7].

The p66 chain has a catalytic site for DNA polymerization: the fingers, palm, and thumb subdomains form a cavity for the binding of the template, primer, two divalent cations, and dNTPs for DNA synthesis [1], as seen in other DNA polymerases.

Although we did expect to detect some Thumb subdomain-like fold that would stabilize the positions of Zn fingers, the discovery of the entire second polymerase and exonuclease module was highly surprising.