Sentence examples for throughput selection from inspiring English sources
Our study demonstrates that yeast display can be used as a high throughput selection platform to reprogram the "nonribosomal code" of A-domains.
In particular landscape phages with multivalent display of target-specific peptides which enable the phage particle itself to become a nanoplatform creates a paradigm for high throughput selection of nanoprobes setting the stage for personalized cancer management.
M. Sproll (Martinsried, Germany) presented another technology platform developed by Morphosys for high throughput selection and editing of human antibodies.
There are several examples of successful isolation of antibodies against various antigens from different phage displayed antibody libraries [ 11, 17, 33, 35, 43], including high throughput selection [ 44].
Conventional IgGs (mAb and PAb) are about 150 kDa, while the antigen-binding fragment, a variable domain of heavy chain antibody (VHH), is about 15 kDa, making it suitable for construction of a high throughput selection system, such as phage, yeast, or ribosome.
Second, it is a high-throughput selection method, which can efficiently select thousands of clones at one time, in contrast with the antibiotic screening, which is limited to approximately 100 clones at a time.
Here, we adapted this assay to develop intrabody selection after Tat export (ISELATE), a high-throughput selection strategy for the identification of solubility-enhanced scFv sequences.
In addition, they are amenable to rational improvement or ab initio design and suitable for high-throughput selection and diagnostic procedures (Gilbreth and Koide, 2012).
While reagentless nucleic acid biosensors may ultimately prove less sensitive or robust than the reagentless protein biosensors, it is nonetheless likely that nucleic acid biosensors are much more amenable to generation by high-throughput selection method.
In this report, we have developed a high-throughput selection method, based on T7 phage display and chromatin immunoprecipitation, to isolate chromatin-binding factors expressed in mouse embryonic stem cells using primary mouse embryonic fibroblast chromatin.
Importantly, our method does not rely on competition between clones and thus eliminates a common limitation of high-throughput selection methods in which the most stable variants are recovered predominantly.
