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However, the use of new lipidomics analytical strategies, with increased sensitivity and throughput, has identified new FA-derived bioactive metabolites with new subjacent molecular mechanisms of action.
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Recent high throughput analysis has identified many more genes that are methylated at far upstream CGIs and even in coding regions [6].
High-throughput sequencing of plant genomes has identified a number of SBP-box genes at the genomic scale.
A high-throughput screen of small molecules has identified that certain β-lactam antibiotics can stimulate the expression of glutamate transporters by astrocyte and thereby enhance glutamate uptake sufficiently to reduce excitotoxicity, and provide neuroprotection in animal models of stroke and ALS [ 199].
To gain insights into the transcriptional regulatory networks in ESC cells, ChIP coupled with ultra-high-throughput DNA deep-sequencing (ChIP-seq) has identified the association of the core transcriptional regulatory Oct4/Sox2/Nanog/Tcf3 complex to a number of miRNA promoters (Marson et al, 2008).
Several high throughput studies have identified miRNA and lncRNA species that are associated with melanoma.
Recently, high-throughput techniques have identified 58648 human lncRNAs [ 2].
Technological advances including high-throughput sequencing have identified numerous tumor-specific genetic changes in pediatric and adolescent cancers that can be exploited as targets for novel therapies.
Recent high-throughput techniques have identified several classes of ncRNAs, including micro RNAs (miRNAs), small-interfering RNAs (siRNAs), and PIWI-interacting RNAs (piRNAs).
Reduced pI forms of metazoan PABP1 in two-dimensional SDS/PAGE [ 31, 32] have been interpreted as indicative of potential phosphorylation, and high-throughput studies have identified putative phospho-sites [ 15, 33, 34].
Recent high-throughput studies have identified the genes whose expression is affected by these different regulatory factors and the binding sites of nucleoid proteins along the genome (Blot et al. 2006; Bradley et al. 2007; Peter et al. 2004; Lucchini et al. 2006; Oshima et al. 2006; Grainger et al. 2006; Wade et al. 2007; Cho et al. 2008; Kahramanoglou et al. 2011).
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