Sentence examples for throughput array from inspiring English sources
On the other hand, using high throughput array and other technologies, it is for example possible to simultaneously analyze thousands of genes or gene products (RNA and proteins), resulting in an individual gene or gene expression profile ('signature'signature
To examine the utility of the SNP set for genomic research, a high throughput array was constructed and used to genotype a collection of ovine populations.
Illumina Immunochip, a high-density throughput array designed to fine-map immune-related loci [ 24], was used to obtain genotyping data from the rs6896969 SNP in the PEARL, PAZ, EAC, Wichita, and NDB cohorts.
To carry out this analysis we used a second independent set of 101 ductal invasive breast tumors for which copy number profiles and Affymetrix High Throughput Array (HTA) GeneChip® expression data were available (Chin et al., submitted).
This comparison indicated that among the seven miRNAs tested, miR-1303, miR-516b and miR-564 showed upregulation in both high throughput array and qRT-PCR, whereas miR-144 and miR-935 showed downregulation in both the array and qRT-PCR assay.
Overall these results indicate about 60% validation (6/9) in terms of similar state of expression (up or down) in both the high throughput array and qRT-PCR, however the exact fold change level is different between the two systems as expected.
The use of synthetic guide RNAs is also uniquely suited to genome-scale high throughput arrayed screening, particularly when using complex phenotypic assays for functional genomics studies.
As demonstrated in our previous report, miRNA profiling of LPS-treated RAW264.7 macrophage cells was performed by the initial high throughput array-based screen and further qRT-PCR validation, and the downregulation of mmu-miR-27a-5p was detected [ 17].
To facilitate multiplatform comparison, for each of the high throughput arrays in CellMiner, we have used the vendor-supplied annotations corresponding to gene symbols and stored them along with array data in a MySQL table.
The newborn blood DNA methylation pattern seems to be affected also by in utero exposure to low concentrations, as shown by the results of a prospective American birth cohort study using high throughput arrays [ 59].
Such architecture is analogous to slice cultures of the developing neural tube (Fig. S1A, ESI †), and it is uniquely generated in a high throughput arrayed fashion using the spatiotemporal control afforded by micropatterned, clickable culture substrates.
