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RouteSearch [40] maximizes atoms conserved throughout the pathway using a heuristic scoring function.
The first and last replica represented reactant and product conformations, respectively, and were fixed throughout the pathway minimizations.
It appears that isolate 9.1 is not regulated to maintain the same flux throughout the pathway to the same extent as P. putida.
It has long been known that neurons throughout the pathway are sensitive to whisker motion direction [2] [8].
The recycling of GluR2-containing AMPARs appears to be carried out by the association with endosomal proteins and peripheral factors throughout the pathway.
Although an ortholog for the glycerol uptake facilitator protein (GlpF) is absent, the presence of enzymes scattered throughout the pathway suggests that M. suis uses glycerol, as well as fructose, to generate phospholipids (cardiolipin).
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The HQMn is the second abundant in January for HQderm for both pathways in June, while the highest was estimated throughout the pathways in April for all ages, respectively.
Likewise, a survey of genes throughout the D. melanogaster immune system found that the trend of elevated rates of adaptive evolution observed in immune genes overall is primarily driven by genes in the Imd and RNAi pathways (Obbard et al. 2009b), although adaptation is not uniform throughout the pathways.
The metabolic interaction catalysed by HMGCR is significantly upstream of cholesterol biosynthesis and we show that the impact of a statin-like treatment is to suppress flux throughout most of the pathway.
The bile acid synthesis pathway has two genes with high regulatory load in macrophages, CYP27A1 and ACP2, which are also the highest expressed genes of the pathway throughout the differentiation from monocytes to macrophages (Fig. 7a).
This representation of genes involved throughout the entire pathway, as well as the enrichment across networks from different studies suggests the IIS pathway is strongly implicated in the control of worker sterility.
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