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Mutant FUS is therefore likely to cause ALS through a dominant gain-of-function effect, instead of a loss-of-function effect through titrating and reducing the WT-FUS function.
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Another possibility is that the homeodomain may disrupt transcription by titrating away transcription factors through dimerization.
This observation is intriguing in view of the fact that short-term SCML2 knockdown did not affect BMI1 localization, and suggests that nucleoplasmic SCML2ΔRBR, being still capable of interacting with BMI1 through the SPM domain, might function in a dominant negative fashion, titrating PRC1 away from chromatin.
We talked about titrating dosages, and cognitive behavioral therapy.
Our tour began with a gleaming lab where technicians sat titrating bits of macerated mosquito in test tubes.
Chloride was determined by titrating against AgNO3.
Phenol block of peripheral nerve condition: titrating for optimum effect.
The Cl− was analysed by titrating with standard AgNO3.
Chloride was analyzed by titrating with standard AgNO3.
by titrating Ub into USP4 D1D2 or USP4CD.
Another valuable aspect of EMS mutagenesis is that induced mutation rates are positively correlated with increasing EMS concentration, therefore mutation rates can be titrated through differing amounts of EMS exposure [18].
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