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These results indicate that ZNF703 modulates ER transcriptional activity and may control breast CSC differentiation process through this regulatory mechanism.
Through this regulatory interaction, we have established a plausible link between the nutritional status of the cell and cell replication which was not known to date.
The next challenge will be to understand why this particular small change in DNA appears to be favored over all the other changes that could occur in the regulatory element, and to see if factors that act through this regulatory switch also modify armor structures in natural populations.
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Altogether, these observations suggest that Rad53 negatively regulates Rrm3 and Pif1 through phosphorylation and that this regulatory process counteracts toxic events mediated by Rrm3 and Pif1 at stalled forks.
"We would encourage everyone to share their views through this formal regulatory process," she added.
"They're playing in a world where professional traders dominate even though we think we've gone through this tremendous regulatory revolution," she said.
It has been shown that functional secretion machinery is required for full expression and secretion of Yops through this feedback regulatory mechanism [11], [37].
Through this negative regulatory influence on PP2A activity, MID1 also controls the activity of the mTOR kinase.
Through this complex regulatory loop, miR-34 is able to regulate apoptosis initiation and the onset of cell-cycle arrest in cancer cell lines [ 84- 88].
Transcription factors are involved in this regulatory process through their combinatorial binding with DNA.
Transcription factors (TFs) are involved in this regulatory process through their combinatorial binding to DNA.
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