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Informally, a direct effect acts around a mediating variable of interest, whereas the indirect effect acts through this mediator; "direct" thus refers to all other pathways other than through the mediator being considered.
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Chk1 activation also requires Rad9, but the mechanism through which this mediator facilitates Chk1 phosphorylation by Mec1 is still poorly understood [30].
This mediator acts through the receptor ST2 at the surface of CD8+ T cells, enhancing T cell clonal expansion and was shown to be necessary for the control of RNA and DNA viral infections in mice [37].
This mediator acts through the receptor ST2 at the surface of CD8+ T cells, enhancing T cell clonal expansion and was shown to be necessary for the control of RNA and DNA viral infections in mice [ 37].
Though in tumorigenesis this mediator initiates EMT through activation of Smad and non-Smad signalling pathways [25].
Though in tumorigenesis this mediator initiates EMT through activation of Smad and non-Smad signalling pathways[ 40].
You have to wonder why you couldn't do that through the mediator, or how invested they were on doing anything with a mediator.
The results indicate that risk assessment is influenced by project managers' overconfidence through the mediator of risk awareness.
BMIE and UBMIR did not affect health outcomes directly but indirectly through the mediator of healthcare expenditures.
Overconfidence leads project managers through the mediator of risk awareness, to assess estimated risk occurrence probability and estimated risk impact more optimistically.
Through the mediator effect of imagination, self-efficacy, generative cognition and conscientiousness had strong effects on the academic performance of both science and engineering majors.
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