Through this integrative approach, we selected 70 key candidate associations between structural genes and metabolites, and experimentally validated eight novel associations, two of them showing differential genetic regulation in the two environments studied.
A highly reliable set of protein-protein interactions is predicted through this integrative approach making use of existing protein-protein interaction data from yeast, human, C. elegans and D. melanogaster.
Through the integrative pathway analysis of microenvironmental stresses and oncogenic events in breast tumors, we identified many known and novel correlations between these two sources of tumor heterogeneity.
Consistent with our in vitro results, in vivo metformin administration inhibited ESCC cell growth through the integrative effects of apoptosis, autophagy and cell proliferation as a consequence of metformin-mediated inactivation of Stat3/Bcl-2 pathway.
By employing the gene enrichment function in miRTar [ 28], the putative or experimentally verified miRNA-gene interactions identified through the integrative database searches were mapped to KEGG (Kyoto Encyclopedia of Genes and Genomes) [ 29] to reveal the biological importance of these molecular relationships.
Through the integrative genomics analysis of these functional RNAi datasets in breast and ovarian cancer, we have identified regulators of mitotic arrest and ceramide metabolism as mediators of taxane resistance and confirmed their relevance in clinical trial cohorts [ 40, 46, 48- 50].
With an appropriate tuning of macroporous properties, such monolithic materials have a wide variety of flow-through applications, excellent integrative features, and are the materials of choice for related engineering applications.
Even though unquestionable progress is observed in this issue, through integrative initiatives such as Galaxy [ 32], this complex mixture of applications and databases often constitutes an obstacle for basic researchers, who are actually the potential target audience demanding this information.
The meeting forum seeks to achieve this goal through integrative interactions across multiple platforms of knowledge and people, as shown earlier in Figure 1, and will form the basis of discussions for iCOMOS-2016.
We tested this hypothesis through an integrative analysis of developing mouse and human fetal lung transcriptomes.
Our study addresses this gap through an integrative analysis of transcriptional, metabolomic, and physiological responses to drought in P. virgatum.
