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A potential solution for the problem of low genotyping coverage is to impute untyped SNPs from their nearby genotyped SNPs through their linkage disequilibrium (LD) pattern.
We examined the geographic diffusion of three cholera outbreaks through their linkage with the wind direction: a) the progress of Vibrio cholerae O1 biotype El Tor in Africa during 1970 1971 and b) again in 2005 2006; and c) the rapid spread of Vibrio cholerae O139 over India during 1992 1993.
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Networks of interacting proteins can provide researchers rudimentary understanding in cellular mechanisms; therefore, it is possible to understand the cellular functions of Reishi polysaccharide (F3) through their linkages to characterized receptors.
These three functional groups, PO43−, COO− and R2HNH+, are found in many other naturally occurring molecules, but through their synthetic linkage as shown in Fig. 1a they collectively become a powerful biological agent.
This knowledge transfer did not stop within the CROs but extended to the local universities and pharmaceutical companies through their sophisticated linkage with CROs.
These results indicate that the superposition of large-scale disturbances in the lower and middle troposphere and their linkage through convective enhancement played an important role in the genesis of Fengshen by preconditioning the establishment of a deep upright inner core.
The observation that the proteins elute simultaneously by anion-exchange chromatography but are separated by aerobic SDS-PAGE is consistent with their linkage through the auxiliary cluster that is sacrificed during turnover.
Our data support a tight and biomechanically defined link between structure and the functional ecology of fish skulls, and indicate that certain mechanisms for transmitting motion through their jaw linkages may require particular anatomical configurations, a conclusion that contravenes the concept of "many-to-one mapping" for fish jaw mechanics.
Therefore, we can predict novel meiotic genes through their co-expression linkages with known meiotic genes.
Therefore, FPG testing in the control arm was monitored through their GPs and linkages with laboratory databases, similar to a previous prostate cancer screening trial [ 25].
More importantly, we predicted six new meiotic genes through their co-expression linkages with known meiotic genes, and subsequently used the genetically more amenable yeast system for experimental validation.
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