Sentence examples for through the rac from inspiring English sources

Activated Rac can induce new actin polymerization by stimulating the Arp2/3 complex through the Rac target IRSp53 [23].

In our project, individually and through the RAC, community partners have played an integral role in research design and development of research protocols, including questionnaires and instruments.

During its development, the cochlear epithelium elongates via convergent-extension movements, a mechanism controlled by core PCP signalling mediated through the RAC-JNK pathway.

Importantly, by analogy to the ability of the ERM proteins to negatively regulate Rho signalling, Merlin can negatively regulate Rac signalling (Shaw et al, 2001), perhaps through an association with the Rac regulator Rho-GDI or the Rac effector Pak or by directly controlling membrane association of Rac in some cells (Kissil et al, 2002; Okada et al, 2005).

Conversely, activation of ROCK results in elevation of myosin contractility that enhances bleb formation, coupled to inhibition of mesenchymal migration through the activation of the Rac GTPase protein (GAP) ARH-GAP22 thereby inhibiting Rac-promoted actin polymerization and mesenchymal-type protrusion formation.

In this case, activation of the Rac protein through the guanine exchange factor (GEF) DOCK3 and the GEF-binding domain containing protein NEDD9 signals through WAVE2 to promote mesenchymal migration.

It has been reported that RhoA/ROCK inhibits the Rac pathway and gankyrin activates Rac through the RhoA/ROCK pathway.

LIMK1 functions downstream of the Rac GTPase to regulate actin dynamics through the actin-regulatory protein cofilin (Bernard 2007).

However, the RAC said this should be brought forward to assess the true extent of evasion.

The RAC was bought by private equity firm Carlyle for £1bn in 2011.

Some analysts think a listing could value the RAC at up to £2bn.