Sentence examples for through the iis from inspiring English sources

The experiment lags slightly behind the simulation result at around 5 or 10 minutes, but this is reasonable given that that in the simulation the level of active Akt is set directly whereas in the experiment it must be activated through the IIS pathway, with a delay of the order of a few minutes.

Stress responses controlled through the IIS pathway result in changes in both mRNA synthesis and protein synthesis.

In times of stress, low levels of signaling through the IIS pathway lead to activated Foxo and 4E-BP in addition to inactive S6K.

Interestingly, lifespan extension through the IIS pathway does not depend on these genes, suggesting that kri-1, daf-9, and daf-12 function specifically in incorporating information on the status of the germline into the regulation of lifespan.

However, reduced signalling through the IIS pathway is also associated with increased lifespan and healthspan in model organisms (Clancy et al., 2001; Holzenberger et al., 2002; Barbieri et al., 2003; Tatar et al., 2003; Giannakou & Partridge, 2007; Piper et al., 2008; Selman et al., 2008; Vallejo et al., 2009; Kenyon, 2011; Selman et al., 2011).

A role for dilp2 in the control of aging was also suggested by studies that extended lifespan through the IIS-related factors dFOXO (Hwangbo et al., 2004), Jun-N-terminal kinase (JNK; Wang et al., 2005), and short neuropeptide-F (sNPF, homolog of mammalian NPY; Lee et al., 2008).

Classical explanations of how infectious agents may provoke autoimmunity [ 21] fit into the aforementioned conceptual framework at three levels: first, through the incorrect activation of the IIS – bystander activation; second, through a failure in IIS-AIS communication – epitope spreading; and third, through a non-specific adaptive response – molecular mimicry and superantigens.

This represents a feedback regulation on IIS, as dFoxO, an inhibitor in the IIS pathway, induces the expression of DILP6, an activator of IIS.

DAF-2, an orthologue of the insulin/insulin-like growth factor receptor, modulates the activity of the IIS pathway, through the FOXO transcription factor DAF-16 [18,19].

The IIS pathway regulates cellular growth through two prominent downstream targets of AKT, FOXO and Tuberous Sclerosis Complex (TSC /Target of Rapamycin (TOR) (Jünger et al., 2003; Oldham and Hafen, 2003).

The IIS software is automatically installed on machines by many software packages.