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Think about it: we're the only animals on this planet to walk upright, analyze the universe around us, put themselves in pressurized metal canisters with wings that fly through the are at 500 mph (800 km/h), and go to war with each other.
In summary although many chemopreventive phytochemicals are known to activate cellular antioxidant defenses through the ARE, direct evidence that their chemopreventive effects against mammary carcinogenesis are due to this effect is limited.
TTP also regulates the stability of GM-CSF (granulocyte/macrophage-colony-stimulating factor) mRNA through the ARE, and therefore TTP deficiency is associated with increased production of GM-CSF and with myeloid hyperplasia.
Taken together, the data present novel evidence that oxidative stress in CF epithelia is not resolved through the ARE due to the dysfunction of Nrf-2.
Such a candidate could be Zfp36, which encodes for a protein involved in mRNA stabilization through the ARE (Au Rich Element) sequence [ 70, 71].
Nrf2 binds to the ARE with high affinity only as a heterodimer with a small Maf protein, and the Nrf2/small Maf complex activates gene expression directly through the ARE [ 17].
Similar(50)
But the through line is the same.
Through the door is the entrance hall.
The pass-throughs are fighting back.
Even the jog-throughs are critical.
Through the night is easier.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com