Sentence examples for through substitution with from inspiring English sources

It has also managed to reduce the burden of opioid dependence, primarily through substitution with methadone and buprenorphine.

If these limits are exceeded, and exposure cannot be reduced to acceptable levels through substitution with a less hazardous agent or the use of engineering controls, such as ventilation, then respiratory protection may be necessary.

The CRR21 editing site target (ndhD C383) was either fully edited or the editing site was lost through substitution with a genomic T.

Further constraint of residue 8 through substitution with the achiral aminoisobutyric acid (Aib8) reduced potency by over 10-fold, possibly because of the additional methyl group, which could interfere with EphA4 binding.

Delaying the progression of renal fibrosis and preservation of allograft function should be the goal, which is being achieved through substitution with less nephrotoxic immunosuppressive agents and modification of risk factors, such as adequate control of hypertension, diabetes, hyperlipidaemia, proteinuria (angiotensin blockade), and infections (CMV, BKV, and urine tract infections).

The results indicate that the volume of poplar wood treated by MAN swells about 9% with about 15% of weight percent gain, and MAN chemically bonds to the cell wall through substitution reaction with hydroxyl group, and the grafting adduct mainly remains as an amorphous form.

In particular, we found that, in analogy to DYRKs, HIPK2-Y354 phosphorylatisn is an autocatalytic event and its prevention, through Y354 substitution with non-phosphorylatable amino acids or by using the kinase inhibitor purvalanol A, induces a strong reduction of the HIPK2 S/T-kinase activity on different substrates.

The abnormal phenomena are ascribed to the formation of electron accumulation layers upon Sb doping through substitution of Zn+2 with Sb+3, resulting in surface downward band bending to render as n-type characteristics.

Our findings suggest that a potential way to improve the physical component of QoL might be targeted reduction of sedentary behavior through substitution of inactivity with habitual physical activity.

Our objective was to identify NZ2114 derivatives with improved activity through substitution of His16 and His18 with residues Arginine and Lysine.

Improvement in rotational capacity was engineered in one frame through provision of closer-spaced stirrups near to the joints and another frame through substitution of deformed bars with smooth round bars.