Non-publication and selective reporting jeopardise evidence-based medicine mainly through skewed literature syntheses.
Although there are several theories to explain the mechanism of this relationship, one unifying idea is that allergic inflammation creates an environment suitable for bacterial infection, e.g., through skewing of mucosal inflammation toward a Th2-type response, disruption of immune defense, alteration in epithelial barriers, or mechanical ostial obstruction.
To summarize, T-614 – a novel immunomodulatory drug – appears to protect the joints from inflammation injury and osteoclastic bone resorption through skewing the response from primarily a Th17-driven one, and it does so to a greater degree in combination with MTX.
Due to their bi-directional replication machinery starting from a single finite origin, bacterial genomes show characteristic nucleotide compositional bias between the two replichores, which can be visualised through GC skew or (C-G /(C-G /
However, in the present theory there is only one flexoelectric constant for isotropic material and the coupling is strictly through the skew-symmetric mean curvature tensor.
Although the resulting incidence rate threshold worked for providing two-class training data, the outlier peaks in years 5 through 8 skewed the threshold computation so that it was too large to provide enough HIGH class samples for the validation and testing years of data.
Normality of distributions was investigated through standardised z (skew) values [ 35].
A putative origin of replication (ori) was assigned through cumulative GC skew analysis, because no clear skew in the leading and lagging strands was observed through conventional GC skew analysis (Supplementary Fig. S3).
A more complex possible explanation is that selection could drive this skew through many negative epistatic interactions in the genome (alluded to in Gompert et al. 2012).
By tracing the paths of a great many (100 or more) meridional and skew rays through a lens, with the help of an electronic computer, and plotting the assemblage of points at which all these rays pierce the focal plane after emerging from the lens, a close approximation to the appearance of a star image can be constructed, and a good idea of the expected performance of a lens can be obtained.
