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Wang, X. et al. YY1 restrained cell senescence through repressing the transcription ofp16.
Chen, G. et al. LncRNA SRA promotes hepatic steatosis through repressing the expression of adipose triglyceride lipase (ATGL).
And second, some African leaders will go to tremendous lengths to remain in power, especially through repressing competition.
Yang S, Du J, Wang Z, et al. BMP-6 promotes E-cadherin expression through repressing δEF1 in breast cancer cells.
We recently showed that direct ERα methylation by the multi-specificity histone lysine methyltransferase SMYD2 regulates estrogen signaling through repressing ERα-dependent transactivation.
In our study, we found that overexpression of Ptn-dt could promote the expression of Alk through repressing miR-96 via interacting with HuR, thus enhancing the biologic function of Ptn.
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Similarly, DinJ, the toxin component of the dinJ/yafQ TA module, has been implicated in reducing σ38 levels through directly repressing the transcription of cspE, which in turn positively affects σ38 translation through stabilisation of rpoS mRNA20.
While miRNAs directly repress pluripotent core factors to facilitate differentiation during the differentiation state, they also help stem cells to maintain pluripotency by activating pluripotent cores through directly repressing DNA methylation systems and primarily inhibiting development in the pluripotent state.
Despite the limited number of ESCC cell line and clinical samples employed in our study, we have successfully and experimentally replicated that miR-21 promotes tumour growth and migration in ESCC through directly repressing PDCD4.
Low stabilities are characterized in many transcription factor mRNAs, and transcription factors can regulate gene expression in response to environmental signals through activating or repressing target genes [ 23, 49].
Understanding how genes move through distinct repressed, primed and active chromatin states is central to understanding transcriptional control processes that regulate gene induction.
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