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However, anti-WNT16B, through neutralizing the specific target WNT16B in TME niches, remarkably reversed the epithelial-to-mesenchymal transition-associated tendency (Supplementary Figures S7a and b).
In particular, the thrombin-rhTM complex demonstrates an anti-inflammatory ability through neutralizing HMGB-1 [48] 48], which is known to be a mediator of lethality and is released from necrotic cells or macrophages/activated dendritic cells with potent pro-inflammatory function, which in turn causes shock or MODS when being disseminated in the systemic circulation [49 51].
These BH3-only proteins activate the multi-domain members BAX and BAK either directly, or indirectly through neutralizing the pro-survival BCL-2 family members.
Anti-IFNα antibodies used in functional assays to neutralize sample IFNα could potentially diminish type 1 interferon-inducible gene transcription through neutralizing early secreted reporter cell IFNα, although this possibility is speculative.
Circulating lipoproteins improve the outcome of severe Gram-negative infections through neutralizing lipopolysaccharides (LPS), thus inhibiting the release of proinflammatory cytokines.
IVIg may have a direct antiviral effect through neutralizing activity of enteroviral antibodies.
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Although HSV-1 rapidly diffuses through neutralized CVM, F127-pretreatment did not reduce adhesion between HSV-1 and healthy, acidic CVM.
This function is mediated through TNFR2, since neutralizing the antibody of TNFR2, but not TNFR1, completely blocks PGRN therapeutic function (Guo et al., 2012).
Pro-survival BCL-2 family members protect cells from dying through binding and neutralizing the pro-apoptotic BCL-2 family members.
On television, with the couple's movement through space neutralized by fluid camera work, the sustained tests of the woman's balance that always dominate the "Don Q" adagio made you compare Mishkutenok less to her skating competitors than to the Makarovas, Kirklands and Plisetskayas who have owned the role of Kitri onstage.
While NAC may serve to diminish binaphthoquinone cytotoxicity by neutralizing ROS through increased glutathione production, it also could exert its actions by interacting directly with binaphthoquinones or their derivatives to reduce their cytotoxicity [13], [25].
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