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Specifically, we conducted stratified analyses and tests for multiplicative interaction with inclusion of cross-product terms in the regression models.
There was evidence of multiplicative interaction with CARD8 rs2043211 in which the IL1B rs1143623 minor (risk) allele homozygous genotype appeared to amplify the effect of the minor allele of rs2043211.
Tests of multiplicative interaction with smoking status were significant only for family history of breast cancer (P-interaction=0.03) and age at menarche (P-interaction=0.03).
To achieve this goal, their training programme included IAT, which showed multiplicative interaction with sexual risk.
This first study led to the identification of seven SNPs showing multiplicative interactions with PTPN22 that passed the four filters.
We also observed a greater than multiplicative interaction between tobacco and alcohol, consistent with previous studies [ 13– 13].
This property also allows us to empirically understand the nature of the effect in the additive, multiplicative or other scale, rather than having to begin with an assumption of multiplicative interaction, as when using logistic regression.
The 665 SNPs showing significant heterogeneity were tested for multiplicative interaction in the subset of the NARAC-I sample with a more uniform Northern European ancestry.
We assessed the potential effect modification of the investigated associations by age and gender through additional inclusion of multiplicative interaction terms (age and gender * HRQoL and SRH, respectively) into the applied multivariable Cox models.
In addition, we assessed interaction with race, age, and BRCA status through stratified analyses and statistical tests of multiplicative interaction.
Interaction on the multiplicative scale was tested by the likelihood ratio test, comparing models with and without multiplicative interaction terms.
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