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While some of tests of coculture on c-Jun levels appear to show a difference (ratios<0.95 and a p value of 0.482), the effect is difficult to establish through multiple testing.
To minimize the chance of a type I error through multiple testing, we applied sequential Bonferroni correction (Holm 1979).
One of the drawbacks with GWAS is deriving the correct threshold to use, so that the number of false positives arising through multiple testing is minimized.
All the results were obtained over an average of ten trials, and we have verified that the exact same targets were predicted in both CUDA- miRanda and the original miRanda implementations through multiple testing datasets.
At present a lack of clear hypothesis about which cortisol parameters are associated with future depressive illness may be causing spurious differences in cortisol being identified through multiple testing and selective reporting.
We were able to use this and the large number of compounds for which we had data to characterize many associations, identifying those likely to arise through multiple testing and contrasting those with associations that appeared more compelling.
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The response time of the designed system is also measured through multiple tests under different conditions, and statistical data analysis has been performed.
"The Russian team may have experienced the toughest checks of the Olympics, because they had to go through multiple tests and checked," said Zhukov.
In addition, we have verified that the exact same targets were predicted in both CUDA-miRanda and the original miRanda implementations through multiple test datasets.
Between 2006 and 2010, the overall proportion of women who were susceptible to rubella (even through multiple tests) was 4.4% (N = 20,056), while the proportion of women who were immune was 89.7% (N = 412,431).
Couples who believe that they are truly discordant have often come to this belief through multiple tests, counseling during and prior to the intervention, as well as the belief that God has created this situation so that one parent can take care of the children if the other parent dies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com