Sentence examples for through multidrug from inspiring English sources

It is curable through multidrug therapy.

Cancer cells can develop resistance to taxanes through mutations of the tubulin gene, expression of alternative tubulin isotypes, or drug efflux through multidrug resistant protein pumps [ 124].

Dictyostelium cells may be able to expel cytochalasin A through multidrug resistance pumps of the plasma membrane, allowing the cell to restore the basal parameters including a dephosphorylated AdcA.

The model simulates uptake of arsenite (iAsIII) via aquaporin isozymes 9 (AQP9s), glutathione (GSH) conjugation, methylation by arsenic methyltransferase (AS3MT), efflux through multidrug resistant proteins (MRPs) and the induced antioxidant response via thioredoxin reductase (TR) activity.

Since GSH can bind to trivalent arsenic and is effluxed out of cells through the multidrug resistance protein 1 (MRP1), 20 we thus investigated the level of MRP1 protein in these ovarian cell lines.

The most prominent situation is the acquired-resistance to azoles, mainly by enhancement of its efflux through upregulation of multidrug transporter genes on yeast cells, besides changes in the ergosterol biosynthesis and occurrence of mutations.

The second hypothesis of adaptive response involves an active expulsion of acetate through plasma membrane multidrug resistance transporters, such as Tpo2p, Tpo3p and Aqr1p, whose genes are transcriptionally activated under the control of Haa1p (Fernandes et al. 2005; Tenreiro et al. 2002; Tenreiro et al. 2000).

Nancollas explained that the expertise that developed around leprosy in the 1980s – at the time of a massive push against the disease through the use of multidrug therapy – is being lost as experts retire.

These control efforts, which are the focus of antimalarial strategies established by the WHO, include the dissemination of insecticide-treated netting, the provision of prophylactic drugs to pregnant women, and earlier and more effective treatment of clinical cases, preferably through the use of multidrug "combination therapy" in order to attack drug-resistant parasites.

Overall, this functional DNA nanostructure provides new insights into the design of nanocarriers to overcome multidrug resistance through targeted drug delivery.

The positron emission tomography (PET) imaging is used in the cancer patients successfully to image the multidrug resistance through P-glycoprotein transport using 99 m tetrofosmin and sestamibi as the radiolabeled substrates for the P-glycoprotein [32, 33].