Furthermore, although an interaction between parkin and α-synuclein still awaits confirmation (Dawson and Dawson, 2010), it is possible that overexpression of parkin might be able to rescue α-synuclein-mediated neurodegeneration through mediating PARIS degradation and, in turn, upregulating PGC-1α expression.
Dynamic geometry environments can support learning of geometry through mediating learners' activity.
Entrepreneurial orientation directly and indirectly impacts firm performance through mediating variables such as market orientation and marketing capabilities.
The data we presented here is a strong confirmation of this finding, revealing that CD146 enhances pathological tumor angiogenesis through mediating VEGF pathway.
Rho ROCK signaling is involved in a multitude of cellular processes including migration, morphogenesis, cell adhesion, and cell-cycle progression through mediating cytoskeletal dynamics [136, 137].
In summary, our findings suggest that SOCS1 may promote apoptosis of intestinal epithelial cells at least partly through mediating p53 signaling.
Service interactions between service providers and health care consumers happen daily in health care organizations, and can occur face-to-face or through mediating technology.
Taken together, our study suggested that miR-34a-5p regulated sev-preconditioning induced inhibition of hypoxia/reoxygenation injury through mediating STX1A, provided a potential therapeutic target for anesthetic protection in cardio disease.
It is interesting to research whether VDAC2 is implicated in these sperm functions through mediating corresponding ions.
It has been demonstrated that VDAC2 can form the channel structure in the lipid bilayer and play important roles in cellular functions through mediating the transmembrane ion transport.
It has been shown that therapeutic agents can sensitize tumor cells to TRAIL-initiated apoptosis through mediating TRAIL receptor expression and function [20], [37], [38], [39], [40], [41], [42].
