The use of EIS as an adjunct not only identified extra cases of HG CIN in this group but also, through its higher specificity and negative predictive value, would allow colposcopists to return more women to routine recall, preventing repeat examinations.
Given that Ash2l and its associated proteins are expressed ubiquitously, we hypothesized that Ash2l achieved its specificity through interactions with developmentally regulated transcription factors, such as Ap2δ.
DndB is a predicted Fe-S cluster binding protein, which we hypothesize affects modification specificity through its action as a transcriptional regulator.
The Ntr domain contains three catalytic aspartates, whereas the PAP domain provides nucleotide specificity through its contact with the base in the active site (Martin & Keller, 2007; Lunde et al, 2012; Munoz-Tello et al, 2012; Yates et al, 2012).
That 'coagulating point' precisely expresses a regime that requires and makes possible molecular specificity, but through its globally molar scope and span.
The quality of the model has been evaluated through its measures of sensibility and specificity with establishment of ROC curve and measure of the area under the curve who was 0.742.
The 380s Loop is proposed to be potentially a determinant of SS-specificity and through its involvement in the open-closed transition of the active site during ADPglucose binding as has been suggested for glycogen phosphorylases.
Alternatively, the PHD domain has also been shown to mediate regional specificity and repression through its interactions with transcriptional repressor RP58, HP1beta, histone deacetylatases (HDACs), and SUV39H1 (Datta et al., 2003; Fuks et al., 2001; Fuks et al., 2003).
The intrinsic promiscuity of a hotdog-fold thioesterase can be revealed through determination of its substrate specificity profile by in vitro substrate activity screening.
Thus, the OR-I7 receptor appears to be activated by the octanal gem-diol and, given the structural differences between the aldehyde and gem-diol forms described in the Introduction, likely achieves its aldehyde specificity through sensing the gem-diol form.
