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These three enriched GO functions suggest that miR-148a is related to cancer metastasis and is likely to regulate these three functions through its regulated PIN.
One miRNA, miR-148a, was identified and its function is to decrease tumor proliferation and metastasis through its regulated PIN.
In particular, miR-148a was identified as a potential prognostic marker in gastric cancer patients, with the ability to function as a tumor suppressor through its regulated PIN.
To further explore whether miR-148a affected cancer metastasis through its regulated PIN, a luciferase reporter assay was performed to analyze the relationship between miR-148a and these target genes.
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p53 can further regulate glycolysis through its regulation of PI3K/AKT and mTOR signaling pathways.
Thus, chromatin remodeling may serve as an alternative mechanism to regulate transcription through its influence on a bound TF, and a bound TF may dictate the location of a remodeled nucleosome.
Through its cytoplasmic domain it regulates podocyte actin dynamics [ 11].
Specifically, HIF1-α can inhibit mTOR through its targets Regulated in development and DNA damage responses 1 (REDD1) and BNIP3 [ 30, 31], whereas mTOR inhibition can result in increased HIF1-α translation, resulting in a regulatory loop [ 32].
It is possible that Rho could regulate neuropeptide release through its ability to regulate levels of the membrane-bound second-messenger DAG as the DAG binding protein PKC-1 stimulates neuropeptide release in C. elegans [50].
Tobacco was used traditionally in northern Australia, through trade with Macassan fisherman, but its availability was seasonal and its use regulated through social control mechanisms [ 11, 12, 14].
The aim of this manuscript is to show how specific pathways could be regulated by vitamin B12 and provide a direct mechanism through its role in regulating AdoMet levels.
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