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Taken together our findings show that ESK1 is necessary for the production of functional xylem vessels, through its implication in the laying down of secondary cell wall components.
S100A4 has been extensively studied for its role in metastasis through its implication in angiogenesis, invasion and cell motility.
Finally, it is interesting to note that the TP53INP1 paralog TP53INP2 (also known as DOR for diabetes and obesity related) is also involved in MS through its implication in autophagy (Nowak et al, 2009; Mauvezin et al, 2010; Sala et al, 2014).
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We have recently shown that p66Shc modulates the expression of receptors that control B-cell entry (CCR7) and egress (sphingosine-1-phosphate receptor 1 (S1P1)) through its pro-oxidant activity, suggesting its implication in their trafficking to SLOs.
It is also of clinical relevance due to its implication in virulence, mutagenesis and dissemination of antibiotic resistance through the activation of mobile genetic elements (Abella et al., 2007; Kelley, 2006; Wade et al., 2005).
Indeed, several recent lines of evidence have highlighted the impact of massive hypoxic features on PDA progression through the modulation of tumor metabolism and metastasis onset, and its implication in chemotherapy resistance owing to deficiencies in blood vessels.
Its implication in ALLs has to be explored (Table 3).
Its implication in virus infection has also been reported [ 19].
Its implication in bone development has been only partially evidenced.
However, its implication in AS has not been fully established.
Its implication in PKD has not been shown, though.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com