Sentence examples for through its active from inspiring English sources

In the present study, we showed that kallistatin, through its active site, stimulated SOCS3 expression by activating a cell surface tyrosine kinase, and thus PKC-ERK signaling.

Several other receptors in this family are for lipid hormone-like ligands; this includes vitamin D, which through its activation and release by the kidney functions as a paracrine hormone (Bell 1985) while vitamin A through its active metabolite retinoic acid (RA) functions as a locally released paracrine or autocrine hormone, acting via retinoic acid receptors (RARs).

In the debate over whether to seek membership, many thoughtful critics argued that the U.S. should not lend credibility to the council through its active participation.

The supermarket says that through its Active Kids scheme – which has been going for seven years – over 40,000 nurseries, schools, scout and guide groups and sports clubs have shared over £100m worth of equipment and coaching.

Another possible way ayahuasca may alleviate feelings of depression is through its active ingredient, the psychoactive chemical DMT (dimethyltryptamine), which is known to induce spiritual experiences and revelations.

It is currently unclear whether the systemic and renal haemodynamic effects are caused by MR-proADM itself or predominantly through its active peptide ADM since an active role of MR-proADM is currently unclear.

"We will stay with the comet through its most active phase, and then afterwards through the decay of activity.

Cholesterol can also influence cell function through its biologically active oxidized product-oxysterol (Janowski et al., 1999; Björkhem, 2006; Radhakrishnan et al., 2007).

Whether non-feeding occurred in concert with cold-tolerance physiological changes allowing the species to go through most of its active lifecycle in freezing or near freezing temperatures remains unclear.

The enzyme exposes its active site through interfacial activation.[ 28] Crystal structures of CalA[ 29, 30] reveal a narrow acyl binding tunnel, a wider nucleophile binding cleft, and a flexible lid.[ 31] The wide nucleophile binding pocket may be the reason why CalA shows low enantioselectivity with small secondary alcohols.

Clopidogrel is an anti-platelet agent that works through irreversible binding of its active metabolite to the P2Y12 subtype of adenosine diphosphate (ADP) chemoreceptors on platelets cell membrane.