Sentence examples for through its activation of from inspiring English sources

LKB1 negatively regulates glycolysis through its activation of AMP-activated protein kinase (AMPK), which activates TSC2 to negatively regulate the activity of mTOR [ 48].

TADG-15 appears to play an important role in the development of cancer through its activation of some precursor proteins, of which active forms are crucial for cellular proliferation, cell motility, angiogenesis, and activation of other protease systems during tumour growth and invasion.

Constitutive activity of the MAPK pathway, a model-predicted resistance mechanism, resembles pathway bypass in that it inhibits FOXO3, which would otherwise be accomplished by AKT, but it also overlaps the index pathway through its activation of mTORC1.

Notch signaling regulates Sox8 and Sox9 transcription, though it does not appear to be through its activation of Hes1 and Hes5.

Also, GSK-3β has an important role in promoting inflammatory processes through its activation of the transcription factor NF-κB [7].

These findings provide evidence that TXNL6 is critical for the action of MsrA under oxidative stress conditions and that TXNL6 is likely to play an important role in cataract formation through its activation of MsrA.

In these CML cells the Bcr-Abl kinase overpowers the negative feedback loops initiated by its activation of Lyn through activation of the phosphatase Shp2 that is able to dephosphorylate Cbp/PAG1 thus mitigating its ability to turn off the Lyn signals [ 92].

Our results indicate that the CDDO-MA renders its neuroprotective effects through its potent activation of the Nrf2/ARE pathway, and suggest that triterpenoids may be beneficial for the treatment of neurodegenerative diseases like Parkinson's disease and Huntington's disease.

The cyclic AMP-dependent processes involved in the dedifferentiation and proliferation of SCs occur either through its direct activation of PKA, or due to its role as a "gating" molecule, by regulating the flow of signals through other pathways.

The pro-inflammatory effects of IL-21 may directly arise through its known activation of the STAT3 pathway, which stimulates the production of pro-inflammatory cytokines [4], [8].

It has been demonstrated to have antiproliferative and tumour suppressive functions, particularly through its transcriptional activation of IFN-α and IFN-β (Vaughan et al, 1997; Um et al, 2000).