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Students' phases of model development, reflecting aspects of engineering design, were identified through iterative refinement cycles of analyses to generate more in-depth evidence of students' learning (Lesh and Lehrer, 2000).
Subsequently, through iterative refinement using PHENIX and model building using Coot, the resolution gradually extends to 3.15 Å.
This suggests that B-cell epitope prediction can be systematically developed through iterative refinement extending its applicability to increasingly complex systems, towards the long-term goal of effecting biological outcomes that advance global health [ 10].
Nearly twenty such models have been built so far [ 2], typically through extensive curation work, and, for some of them, through iterative refinement processes where models were progressively improved by comparison with experimental datasets [ 4].
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Koh et al. (2015, p. 40) add that design thinking would be 'best developed through the iterative refinement of artifacts that are being developed to represent design ideas throughout design episodes'.
When facility requirements or production objectives are found to be operationally or economically unacceptable, desired results are obtained through iterative design refinement.
Qualitative simulation would facilitate the iterative refinement of whole-cell mechanistic models through both theoretical prediction and experimental validation.
After three rounds of iterative refinement, the alignments were further corrected manually using a text editor.
Iterative refinement was carried out using Phenix.refine54 and model building was carried out using COOT55.
Inconsistencies among them are resolved via an iterative refinement algorithm.
A projection matching algorithm was applied for the determination of the center and orientation of raw particles in iterative refinement.
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