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The study went through IRB review and received human subjects exempt categorization.
All tissue was obtained through IRB approved protocols at the University of Pittsburgh.
The Mississippi State University Institutional Review Board for the Protection of Human Subjects in Research provided approval for the survey instruments via administrative review on January 22 , 2004through IRB Docket #04-005.
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The primary means to public assurance in medical research is through IRBs.
Samples for this study were obtained from formalin-fixed, paraffin-embedded tissues from University of Chicago HTRC through IRB-approved protocols.
The formalin-fixed, paraffin-embedded tissues samples were acquired from the archives of the University of Chicago Human Tissue Resource Center (HTRC) available to us through IRB-approved protocols.
The research organisation that conducted this study, RTI Health Solutions, a business unit of RTI International (RTI), holds a Federal-Wide Assurance (FWA #3331 effective until 17 June 2014) from the DHHS Office for Human Research Protections that allows us to review and approve human subjects protocols through our IRB committees.
As one participant put it: "It comes down to you have to be assured that the person (a) has the need to access the information, (b) have (sic) gone through whatever IRB requirement, local area, local IRB imposes upon researchers in general and (c) they agree to abide by whatever agreements and standard terms or conditions that the project imposes on people who access the data".
De-identified patient samples of primary and metastatic tumors were obtained through an IRB-approved study supported through the tissue procurement facility of the Lineberger Comprehensive Cancer Center.
To determine whether fascin expression correlated with the clinical course of CRC, we utilized a TMA of colorectal adenocarcinomas for which clinical annotation was available through an IRB-approved database.
Use of the ALL samples was approved through the Institutional Review Board (IRB) of Our Lady Of Mercy Cancer Center and use of the AML samples was approved through the Eastern Cooperative Oncology Group IRB for the E1900 clinical trial.
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