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It is suggested that entosis serves as a homeostatic mechanism to inhibit metastasis through internalizing effector cells.
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Not uncommonly, Holocaust survivors have kept from going insane only through silence, internalizing their trauma and burying it deep inside them.
Here we sought to determine whether AP-2 phosphorylation represents a general mechanism for different receptors internalizing through the clathrin pathway.
Still, a lot of what Will went through was internalized, and his interactions with people already deeply entrenched in his life could only bring so much of that emotional struggle to the surface.
This model postulates individuals may process anger through either externalizing or internalizing the feelings.
Certain types of noncancerous cells may be capable of internalizing ADCs through nonspecific pinocytosis or fragment crystallizable (Fc) region receptor-mediated endocytosis (Lencer and Blumberg, 2005).
This process involves the receptor recognizing a ligand from the extracellular membrane (ECM), internalizing it through clathrin-coated pits and degrading it upon fusion with lysosomes.
For example, it has been shown that myeloma cells decrease OPG availability by internalizing it through binding to glycosaminoglycan side chains of surface syndecan-1 and degradation to lysosomes, thereby regulating its inhibitory effect on RANKL [ 116].
In most cell types, RTKs mainly internalize through clathrin-dependent internalization, converging in the formation of clathrin-coated membrane invaginations, or clathrin-coated pits (CCPs), in a series of highly regulated steps.
The LDL preparations used for uptake assay are modified LDL that are internalized through Scavenger Receptors or through non-receptor mediated fluid-phase macropinocytosis [29].
Bacteria can internalize through root during cultivation and through the stomata of leaf during pre-/post-harvest (Hoelzer et al. 2014).
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