The PRDs are most likely tightly packed through interlinkage by hydrogen bonds and disulfide bridges (Spurny et al. 2007), forming a compact C-terminal globular domain.
"The aim of any antitrust inquiry," he wrote, "should be whether the particular bundle is a strategic bundle, aiming at anticompetitive ends, not whether the bundle achieves its interlinkage through contract or software".
For example, the complex interlinkages with the impacts of climate change on pests, diseases and pollinators, like bees, are largely unknown.
Mr Nelson named these interlinkages "hypertext," implying a relationship outside the one-dimensional reading direction in a document or the two-dimensional layout on a page, and impossible to create in any analog form.
Sarah Wilson, the chief executive of the corporate governance research firm Manifest, said: "Shareholders have been concerned for some time about the interlinkages between Mike Ashley's personal financial arrangements and those of Sports Direct Plc.
"Co-ordination failures between policies on water, energy and land need to be addressed to avoid the negative impacts of these interlinkages," said the report, which aims to "shape global action" in the run-up to next month's Rio+20 UN conference on sustainable development.
If responsibilities between Brussels and national governments are not clearly separated, if subsidiarity the notion that things are best done at the lowest possible level of government is not strongly spelt out, and if financial interlinkages are not clarified, the EU could find that it too heads for a system crash.
This article explores the interlinkages between local livelihood and environmental benefits from the provision of energy to remote rural households through small hydropower development.
After which, the interlinkages between the three levels were identified.
