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Prior stroke is a risk factor for fracture, through immobility decreasing bone mineral density and by gait instability increasing risk for falls.
This process, called cachexia, is estimated to be responsible for at least 20% of cancer deaths through cardiac/respiratory failure (Inagaki et al, 1974) and the patients quality of life is also reduced through immobility.
From an evolutionary perspective, shutdown dissociation might be seen as an adaptive response to life-threatening conditions during which neither flight nor fight is a viable options for survival: since the organism cannot defend itself or escape, it can only minimize harm, through immobility and functional sensory deafferentiation [ 11].
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Similarly the association of COPD may be explained through an immobility or stasis mechanism.
(Satie appended a note to "Vexations," stating that the two-minute-long piece should be played eight hundred and forty times, after the pianist has prepared himself "in advance, and in the utmost silence, through serious immobilities".
Cage took a special liking to a short, gnomic, harmonically directionless 1893 piece called "Vexations," at the beginning of which Satie wrote, "To play this motif eight hundred forty times in a row, it would be advisable to prepare oneself beforehand, in the deepest silence, through serious immobilities".
Specifically, animal studies have demonstrated that proteolysis occurs during immobility through three major pathways: calcium-dependent calpains [ 22], lysosomal cathepsins [ 23], and the ubiquitin-proteasome system [ 24].
It was assessed through the Tonic Immobility Scale, which has been previously translated into Brazilian Portuguese, and has been used in research and clinical settings.
Experts estimate that two million Americans suffer from pressure ulcers each year, usually through some combination of immobility, poor nutrition, dehydration and incontinence.
No actress in the world is able to project more emotion through a mask of immobility than Catherine Deneuve, the enduring French star who gives one of her deepest screen performances in Philippe Garrel's film "Le Vent de la Nuit" ("Night Wind").
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com