Our findings reveal a plausible mechanism by which HDAC inhibitors may disrupt deacetylase function during spermatogenesis, through disruption of Ing2-bound co-repressor complexes.
However, it is possible that c-Myc could be disrupted by other means, such as through disruption of chromatin-dependent signaling.
One mechanism is through disruption of gene function: microsatellite expansions residing in exon or intron sequences disrupt the normal function of the gene product.
Tajideen and his wife faced a 150,000 Euro fine for financial irregularities, a small percentage of their losses through disruption to their businesses.
"They can potentially threaten all native fish species through disruption of the local ecosystem and disease transmission," Mr. Panzone wrote in an e-mail.
Information technology evolves through disruption waves.
Further, test compounds resulted in inhibition of cell migration through disruption of F-actin protein assembly.
Bortezomib, a proteasome inhibitor, modulates apoptosis and cell cycle through disruption of protein degradation.
Annona muricata extract induced apoptosis in human cancer cell through disruption of mitochondrial membrane potential (Pieme et al. 2014).
Taxanes may partly mediate their effect in castration-resistant prostate cancer (CRPC) through disruption of androgen-receptor trafficking along microtubules.
We have seen a pervasive pattern in every industry that has been transformed through disruption, and health care is no exception.
