Sentence examples for through destabilization from inspiring English sources

Furthermore, the pH-sensitive core of the nanoparticle platform led to controlled drug release through destabilization in acidic conditions.

Compounds from this privileged structure-based library were identified as antimitotic agents acting through destabilization of tubulin polymerization.

Building upon the concepts of kinetic proofreading and our understanding of M.HhaI, we describe how a 16-fold specificity enhancement achieved with a double mutation at the loop/active site interface is acquired through destabilization of intermediates prior to methyltransfer rather than disruption of direct interactions between the enzyme and the substrate for M.HhaI.

Aß renders neurons more vulnerable to excitotoxic insults through destabilization of calcium homeostasis [7].

In particular, we suggest the reduced enzyme activity of the F46Y and L172Q variants may be mediated through destabilization of the cofactor.

MDSCs are classically known to decrease CTL response, mostly through destabilization of T-cell receptors and decreased expression of certain CD3 subtypes, ultimately leading to CTL apoptosis.

Computational modeling of the experimentally identified mutations showed that these mutations reduced the binding affinity through one of the three scenarios: through SCF destabilization, through elimination of favorable SCF/c-Kit intermolecular interactions, or through allosteric changes.

It is triggered by the extrinsic pathway through the activation of proapoptotic receptors or by the intrinsic pathway through the destabilization of mitochondria in response to various forms of cell injury or stress.

This usurpation of rights intended for people by "corporate persons" has led to laws supporting unlimited growth - the sole corporate value of profit - at the expense of quality of life, strong communities, and the future of the planet (from a human perspective) through climate destabilization.

It has also a cationic anti-microbial peptide (CAMP) function that leads to bacterial death likely through the destabilization of the cytoplasmic membrane [11] [13].

They negatively regulate thousands of target genes through mRNA destabilization and/or translational suppression 1.