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The representative compound 30 DDO-20844) inhibited proliferation and induced apoptosis of MV4-11 cells through deregulating expression level of Hoxa9 and Meis-1 genes, which emphasized our compounds were on-target.
The chief executive of the budget carrier said Europe had allowed Britons to enjoy affordable holidays through deregulating the airline industry, and that Ryanair would invest less in the UK if it were outside the EU.
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The right approach to energy security is through deregulated markets and diversified sources of supply, not via subsidies in the name of "energy independence".
Besides mutations, p53 is thought also to be functionally inactivated through deregulated upstream and downstream regulators [1] [3].
One should also investigate whether some host factors elicit a disease phenotype through deregulated retrotransposon activity.
Our data, which are mostly concordant with previous observations, suggest that EGFR overexpression may result in a more aggressive tumour behaviour [ 38], through deregulated function of these genes.
Previous reports suggested that elevated BIM expression alone (through deregulated E2F-1 activity) by HDACi was sufficient to induce apoptosis in E1A-expressing human fibroblasts.
An additional complication is the tremendous plasticity of cancer cells and their ability to acquire stem cell characteristics through deregulated expression of just a few genes (Takahashi and Yamanaka 2006; Mani et al. 2008; Morel et al. 2008).
and played a major role in pushing legislation through Congress deregulating the industry, opening the door to its dramatic growth.
Bonuses entered British corporate culture in the 1980s as a device for enabling bosses to line their pockets with some of the cash swilling through newly deregulated balance sheets.
Previous work from our laboratory demonstrated that CC2238/ αANP induces detrimental vascular effects through a deregulated activation of NPR-C.
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CEO of Professional Science Editing for Scientists @ prosciediting.com